What are exosomes?
Also called extracellular vesicles, they are present in almost every cell, tissue and fluid of the human body. They help cells signal to one another and maintain homeostasis - the balance - of the tissue. Researchers have described 9,769 proteins, 2,838 miRNAs, 3,408 mRNAs and 1,116 lipids in the exosomal cargo. These exosomes interact with the receiving cells through their surface receptors and internalise - enter - the host cells through micropinocytosis.
Advances in regenerative medicine have made it possible to isolate exosomes from mesenchymal stem cells (MSC) of human, animal and plant origin, and have revealed how much they offer in diagnosis, in delivering medicines and, not least, in aesthetic and regenerative medicine. Those cells have the greatest regenerative potential there is, being able to follow various lines of cell differentiation.
Through paracrine signalling, exosomes set the repair of damaged tissue in motion, their restorative effects reaching from the strengthening of the skin barrier to the promotion of angiogenesis. That breadth of regenerative action is vital in re-establishing the integrity of the dermis and revitalising tissue that has been compromised.
Many studies in vitro and in vivo have demonstrated the safety, the efficacy and the therapeutic potential of exosomes in various cancers and in neurodegenerative, cardiovascular and orthopaedic disease, opening up prospects we could not even have imagined a few years ago.
Exosome therapy at our clinic
As always, we keep pace with everything new, innovative and effective on the aesthetics market, and we have brought the two best known and most effective kinds of exosome product into the clinic: the plant-derived ones from ExoCoBio and those from Dp Dermaceuticals™. They are delivered into the target tissue (the scalp, the face, the hands, the décolletage and so on) by microneedling, fractional radiofrequency or CO2 laser.
Exosomes Dp Dermaceuticals™
Exosomes promote the healing of wounds by closing them faster, by reducing scarring and the formation of scars, by regulating how the collagen fibres are distributed and by supporting the regeneration of the skin's appendages - the hair and the sebaceous glands, the nerves and the blood vessels - through inhibition of the TGF-β receptor.
Dp Dermaceuticals™ developed MG-EXO-SKIN™, exosomes of human origin, working with the most progressive innovators in stem cell research. DermapenWorld™ obtained ethically produced exosomes, multipotent and extremely versatile.
MG-EXO-SKIN™ is transforming aesthetic treatments with the dual HylaFuse™ and Calphasome™ delivery systems.
EXO-SKIN™ contains an unmatched complex of redox agents, targeting reactive oxygen species with antioxidant bioflavonoids, tannins and polyphenols. This skin-correcting complex is certified and tested for purity, potency and safety. As a new regenerative force, MG-EXO-SKIN™ does away with the complications of autologous procedures, to restore the functions of the skin.
Combining the therapy with microneedling or other devices lets the regenerative capacity of exosomes speed up the results of any procedure, helping improve a great many skin conditions, including those caused by the sun, by ageing, by rosacea and by pigmentation.
To carry the results of the in-clinic procedures with MG-EXO-SKIN™ further, patients can continue their skin rejuvenation protocols at home with Dp Dermaceuticals™ EXO-SKIN™ (a topical exosome product).
What exosome therapy does for you
- The skin's regenerative potential, at its fullest
- Natural cell repair, enhanced
- An improvement in aged-looking skin, in pigmentation and in redness
- Skin revitalised and refreshed
Exosomes have been shown to improve the synthesis of collagen, angiogenesis and cell proliferation, and to support the healing of wounds.
An exosome is a tiny vesicle found in cells, particularly in human stem cells. They carry biomolecules such as proteins, lipids and nucleic acids, and act as messengers from the stem cells to other cells. They play a vital part in the communication between cells, in the healing of tissue, and in regeneration and cell repair.
It should be said plainly that exosomes do not alter the DNA of a cell; this is not gene therapy.
What human exosomes do for you
- Promote the healing of wounds
- Support the synthesis of collagen and elastin
- Support cell differentiation
- Improve angiogenesis
- Inhibit scarring
Ask your doctor whether this remarkable therapy is right for you
ExoCoBio exosomes
ExoCoBio, under the ASCE+ brand, is the first and foremost biopharmaceutical company to have developed a therapy based on plant exosomes, and holds more than 22 patents worldwide to date. Their studies show extraordinary effects on the regeneration and rejuvenation of the skin, and on the redensification of hair on the scalp in women and men.
As described above, exosomes are fundamental to the communication between all cells; they act as an ambassador for each cell, and come in two forms, one for the scalp (HRLV) and one for the glabrous skin of the face, the hands, the neck and the décolletage (SRLV).
Exosomes bring many benefits, their composition including:
- 1008 kinds of growth factor and of protein.
- 200 kinds are effective in rejuvenating the skin.
- 598 kinds of microRNA.
- 56 kinds are anti-inflammatory, maintain the skin barrier, work against ageing, brighten the skin and are effective in cell proliferation.
- 46 kinds play an important part in inhibiting thymic stromal lymphopoietin (TSLP), the cytokine behind atopic dermatitis and itching.
- 373 kinds of lipid, among them the ceramides, fatty acids and sterol lipids that form the skin barrier.
- 6 kinds of peptide, 19 kinds of amino acid, glutathione, hyaluronic acid, vitamins and minerals.
The ASCE SRLV products are strongly anti-inflammatory and powerfully antioxidant. Central to the many good things exosomes do is their capacity to stimulate the regeneration of cells.
Exosome therapy also helps reduce the synthesis of melanin in the cells, easing hyperpigmentation and restoring the skin's natural radiance after exposure to ultraviolet light. That function is crucial in achieving an even skin tone and in improving how the skin glows overall.
It is one of the best answers to the rejuvenation of the skin, the result of exosomes and active ingredients working together. Exosomes carry numerous growth factors, anti-inflammatory cytokines and the genetic material responsible for repairing tissue and modulating immunity. They promote the regeneration of the skin, remarkable healing, and the keeping of its firmness. The product hydrates the skin with hyaluronic acid. It contains retinol and vitamin C, which work against wrinkles and brighten the skin.
What exosomes do, in short
- Anti-inflammatory efficacy
- Antioxidant potential
- Regenerative dynamics
- Modulation of melanin and better radiance
ASCE Hair Therapy HRLV is distinguished by its fourfold mechanism of action, addressing the key aspects of the health of the scalp and the hair:
- Stimulating the cell metabolism of the hair follicle
- Revitalising and regenerating the cells of the scalp to improve the vitality of the follicles
- An anti-inflammatory response, of benefit in certain dermatitides too
- Normalising the cycles of hair growth
It regenerates the hair through its enhanced composition, since 1 ml of the preparation carries a high dose of exosomes. It is ideal for treating androgenetic and telogen effluvium in women and men.
One vial of the preparation holds 20 mg of powder with 10 billion exosomes and 0.05% biotin. The product supports the growth phase of the hair through 1008 different kinds of protein and growth factor that stimulate regeneration. It also carries 598 kinds of miRNA, which are anti-inflammatory on the scalp.
Why choose exosome therapy for the scalp?
Choosing ASCE Hair Therapy means choosing an innovative course of care for hair loss and conditions of the scalp. It offers a non-invasive, highly effective alternative to the traditional treatments, with the added benefits of safety and efficacy through the targeted action of exosomes. ASCE Hair Therapy is ideal for anyone with thinning hair, scalp problems, or simply looking to improve the health and the look of their hair.
